Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.

نویسندگان

  • J A Wisniewski
  • D E Moody
  • B D Hammock
  • L R Shull
چکیده

Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.

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Interlobular Distribution of Hepatic Xenobiotic- Metabolizing Enzyme Activities in Cattle, Goats and Sheep 1

Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b s and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsom...

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The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats

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عنوان ژورنال:
  • Journal of animal science

دوره 64 1  شماره 

صفحات  -

تاریخ انتشار 1987